RAF Typhoon FGR4s have operated alongside French aircraft in a joint strike targeting an hidden munitions depot in Syria used by the Daesh militant organization, as stated by the UK's MoD.
The site, located using reconnaissance, was thought to be storing arms and explosives, the announcement noted, and was situated in mountainous terrain just north of Palmyra in Syria's central region.
"Our aircraft utilized precision-guided Paveway IV munitions to strike a several entry passages providing entry to the site... preliminary assessments suggest the target was engaged successfully," the MoD said.
There was no indication of any civilian casualties in the strike on Saturday evening and each participating jet made a safe return, the MoD added.
The Typhoon FGR4s were supported by a Voyager aerial refuelling aircraft.
IS - referred to as Daesh - established extremist governance over large swathes of Iraq and Syria prior to its 2019 collapse.
"This strike shows our UK leadership, and determination to operate in unison with our partners, to eradicate any resurgence of the terrorist group and their harmful and extremist ideologies in the Middle East," Britain's Defence Chief the minister said.
RAF aircraft have conducted surveillance missions over Syrian airspace to "prevent any attempted resurgence" of IS subsequent to its defeat at the Baghuz confrontation in the year 2019, the ministry said.
"I want to thank every member of British forces who took part in this mission for their professionalism and their courage," the Defence Secretary commented. "They were part of thousands of British personnel stationed over the holidays. This mission, to take out terrorist threats who pose a risk to our security, highlights how our armed forces are ready to step up, throughout the year, protecting the UK domestically and powerful internationally."
In December, the US military carried out what it described as a "large-scale strike" on Islamic State objectives in Syria, after an attack claimed the lives of two US servicemembers and a civilian linguist in Palmyra.
The UN says Daesh still boasts roughly 5-7 thousand combatants in both countries.